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Joachim Krug ICTS Lectures June 2019

Joachim Krug

Playlist from ICTS June 2019

Screenshots from lectures on google photos

Course 1 :** Statistical physics of biological evolution by **Joachim Krug (Cologne, Germany)

Lecture 1 : Stochastic models of population dynamics: Wright-Fisher and Moran models; fixation; diffusion theory.

  • Lenski 12 populations of E. coli evolved under constant nutrient-poor conditions since 1988

    • Some populations turned into hypermutators with higher relative fitness
  • Compare fitness by combining strain 1 and strain 2 in 50% proportions and observe the population dynamics that arise in a given environment. The slope of the ratio of population sizes is a reasonable proxy for fitness.
  • \[\mathbb{E}(H'|n) = H(l-\frac{l}{m}) \lt H\]

Lecture 2 : Fitness landscapes I: Epistasis and sign epistasis; sequence spaces; measures of fitness landscape ruggedness.

Lecture 3 : Fitness landscapes II: Random field models; accessibility percolation

Lecture 4 : Dynamics on fitness landscapes I: Origin-fixation models; mutational landscape model and adaptive walks.

Lecture 5 : Dynamics on fitness landscapes II: Rank order processes; extreme value theory in evolutionary biology.